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Tadalafil is a PDE5 inhibitor, currently marketed by the name Cialis to treat erectile dysfunction. Tadalafil has now also been approved to treat pulmonary arterial hypertension, and has been used for other conditions. Pulmonary arterial hypertension (PHT) is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, which together are known as the lung vasculature. PHT leads to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion. Pulmonary hypertension can potentially be a severe disease with a leading to significantly decreased exercise tolerance and increased risk of heart failure.

Unlike Viagra (Sildenafil) or Levitra (Varfenadil), Cialis (Tadalafil) is the only one of the three that is also offered as a once-daily medication. Moreover, tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is currently under regulatory review in other regions for this condition.

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Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrites (such as the sex drug amyl nitrite) within this timeframe may increase the risk of life-threatening hypotension.

ce people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina (such as glyceryl trinitrate spray), these patients should seek immediate medical attention if they experience anginal chest pain. In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.

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